CellLine¶
lamindb provides access to the following public CellLine ontologies through bionty:
Here we show how to access and search CellLine ontologies to standardize new data.
import bionty as bt
import pandas as pd
PublicOntology objects¶
Let us create a public ontology accessor with .public
method, which chooses a default public ontology source from Source
.
It’s a PublicOntology object, which you can think about as a public registry:
celllines = bt.CellLine.public(organism="all")
celllines
→ connected lamindb: testuser1/test-public-ontologies
PublicOntology
Entity: CellLine
Organism: all
Source: clo, 2022-03-21
#terms: 39037
As for registries, you can export the ontology as a DataFrame
:
df = celllines.df()
df.head()
name | definition | synonyms | parents | |
---|---|---|---|---|
ontology_id | ||||
CLO:0000000 | cell line cell culturing | a maintaining cell culture process that keeps ... | None | [] |
CLO:0000001 | cell line cell | A cultured cell that is part of a cell line - ... | None | [] |
CLO:0000002 | suspension cell line culturing | suspension cell line culturing is a cell line ... | None | [CLO:0000000] |
CLO:0000003 | adherent cell line culturing | adherent cell line culturing is a cell line cu... | None | [CLO:0000000] |
CLO:0000004 | cell line cell modification | a material processing that modifies an existin... | None | [] |
Unlike registries, you can also export it as a Pronto object via public.ontology
.
Look up terms¶
As for registries, terms can be looked up with auto-complete:
lookup = celllines.lookup()
The .
accessor provides normalized terms (lower case, only contains alphanumeric characters and underscores):
lookup.hek293
CellLine(ontology_id='CLO:0001230', name='HEK293', definition=None, synonyms='293|HEK-293|293 HEK|293 cell|Human Embryonic Kidney 293|HEK 293', parents=array(['CLO:0037236'], dtype=object))
To look up the exact original strings, convert the lookup object to dict and use the []
accessor:
lookup_dict = lookup.dict()
lookup_dict["HEK293"]
CellLine(ontology_id='CLO:0001230', name='HEK293', definition=None, synonyms='293|HEK-293|293 HEK|293 cell|Human Embryonic Kidney 293|HEK 293', parents=array(['CLO:0037236'], dtype=object))
By default, the name
field is used to generate lookup keys. You can specify another field to look up:
lookup = celllines.lookup(celllines.ontology_id)
lookup.clo_0000469
CellLine(ontology_id='CLO:0000469', name='immortal cat mixed endoderm/mesoderm-derived structure-derived cell line cell', definition='An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from cat.', synonyms=None, parents=array(['CLO:0000213'], dtype=object))
Search terms¶
Search behaves in the same way as it does for registries:
celllines.search("hek293").head(3)
name | definition | synonyms | parents | |
---|---|---|---|---|
ontology_id | ||||
CLO:0001230 | HEK293 | None | 293|HEK-293|293 HEK|293 cell|Human Embryonic K... | [CLO:0037236] |
CLO:0037237 | 293-derived cell | None | 293|HEK-293|293 HEK|HEK293|HEK 293 | [CLO:0037236] |
CLO:0037352 | ER-alpha-UAS-bla HEK293 | HEK293 cells modified with a beta-lactamase re... | None | [CLO:0037237] |
By default, search also covers synonyms and all other fileds containing strings:
celllines.search("Human Embryonic Kidney 293").head(3)
name | definition | synonyms | parents | |
---|---|---|---|---|
ontology_id | ||||
CLO:0001230 | HEK293 | None | 293|HEK-293|293 HEK|293 cell|Human Embryonic K... | [CLO:0037236] |
CLO:0037372 | HEK293T cell | None | 293T|293-T|HEK 293 T|HEK-293T|HEK293T|293tsA16... | [CLO:0037237] |
CLO:0037373 | HEK293T-derived cell | None | Human Embryonic Kidney 293T-derived cell | [CLO:0037237] |
Search specific field (by default, search is done on all fields containing strings):
celllines.search(
"suspension cell line",
field=celllines.definition,
).head()
name | definition | synonyms | parents | |
---|---|---|---|---|
ontology_id | ||||
CLO:0000002 | suspension cell line culturing | suspension cell line culturing is a cell line ... | None | [CLO:0000000] |
Standardize CellLine identifiers¶
Let us generate a DataFrame
that stores a number of CellLine identifiers, some of which corrupted:
df_orig = pd.DataFrame(
index=[
"253D cell",
"HEK293",
"2C1H7 cell",
"283TAg cell",
"This cellline does not exist",
]
)
df_orig
253D cell |
---|
HEK293 |
2C1H7 cell |
283TAg cell |
This cellline does not exist |
We can check whether any of our values are validated against the ontology reference:
validated = celllines.validate(df_orig.index, celllines.name)
df_orig.index[~validated]
! 1 unique term (20.00%) is not validated: 'This cellline does not exist'
Index(['This cellline does not exist'], dtype='object')
Ontology source versions¶
For any given entity, we can choose from a number of versions:
bt.Source.filter(entity="bionty.CellLine").df()
Show code cell output
uid | entity | organism | name | in_db | currently_used | description | url | md5 | source_website | dataframe_artifact_id | version | run_id | created_at | created_by_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
id | |||||||||||||||
30 | 6LyR | bionty.CellLine | all | clo | False | True | Cell Line Ontology | https://data.bioontology.org/ontologies/CLO/su... | ea58a1010b7e745702a8397a526b3a33 | https://bioportal.bioontology.org/ontologies/CLO | None | 2022-03-21 | None | 2024-12-03 08:31:03.366267+00:00 | 1 |
31 | 2zHO | bionty.CellLine | all | depmap | False | False | Dependency Map | s3://bionty-assets/df_all__depmap__2024-Q2__Ce... | https://depmap.org/portal/ | None | 2024-Q2 | None | 2024-12-03 08:31:03.366291+00:00 | 1 |
# only lists the sources that are currently used
bt.Source.filter(entity="bionty.CellLine", currently_used=True).df()
uid | entity | organism | name | in_db | currently_used | description | url | md5 | source_website | dataframe_artifact_id | version | run_id | created_at | created_by_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
id | |||||||||||||||
30 | 6LyR | bionty.CellLine | all | clo | False | True | Cell Line Ontology | https://data.bioontology.org/ontologies/CLO/su... | ea58a1010b7e745702a8397a526b3a33 | https://bioportal.bioontology.org/ontologies/CLO | None | 2022-03-21 | None | 2024-12-03 08:31:03.366267+00:00 | 1 |
When instantiating a Bionty object, we can choose a source or version:
source = bt.Source.filter(
name="clo", version="2022-03-21", organism="all"
).one()
celllines= bt.CellLine.public(source=source)
celllines
PublicOntology
Entity: CellLine
Organism: all
Source: clo, 2022-03-21
#terms: 39037
The currently used ontologies can be displayed using:
bt.Source.filter(currently_used=True).df()
Show code cell output
uid | entity | organism | name | in_db | currently_used | description | url | md5 | source_website | dataframe_artifact_id | version | run_id | created_at | created_by_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
id | |||||||||||||||
1 | 33TU | bionty.Organism | vertebrates | ensembl | False | True | Ensembl | https://ftp.ensembl.org/pub/release-112/specie... | 0ec37e77f4bc2d0b0b47c6c62b9f122d | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365482+00:00 | 1 |
6 | 6bbV | bionty.Organism | bacteria | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/bacte... | ee28510ed5586ea7ab4495717c96efc8 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365673+00:00 | 1 |
7 | 6s9n | bionty.Organism | fungi | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/fungi/releas... | dbcde58f4396ab8b2480f7fe9f83df8a | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365700+00:00 | 1 |
8 | 2PmT | bionty.Organism | metazoa | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/metazoa/rele... | 424636a574fec078a61cbdddb05f9132 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365726+00:00 | 1 |
9 | 7GPH | bionty.Organism | plants | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/plant... | eadaa1f3e527e4c3940c90c7fa5c8bf4 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365751+00:00 | 1 |
10 | 4tsk | bionty.Organism | all | ncbitaxon | False | True | NCBItaxon Ontology | s3://bionty-assets/df_all__ncbitaxon__2023-06-... | 00d97ba65627f1cd65636d2df22ea76c | https://github.com/obophenotype/ncbitaxon | None | 2023-06-20 | None | 2024-12-03 08:31:03.365776+00:00 | 1 |
11 | 4UGN | bionty.Gene | human | ensembl | False | True | Ensembl | s3://bionty-assets/df_human__ensembl__release-... | 4ccda4d88720a326737376c534e8446b | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365801+00:00 | 1 |
15 | 4r4f | bionty.Gene | mouse | ensembl | False | True | Ensembl | s3://bionty-assets/df_mouse__ensembl__release-... | 519cf7b8acc3c948274f66f3155a3210 | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365901+00:00 | 1 |
19 | 4RPA | bionty.Gene | saccharomyces cerevisiae | ensembl | False | True | Ensembl | s3://bionty-assets/df_saccharomyces cerevisiae... | 11775126b101233525a0a9e2dd64edae | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.366000+00:00 | 1 |
22 | 3EYy | bionty.Protein | human | uniprot | False | True | Uniprot | s3://bionty-assets/df_human__uniprot__2024-03_... | b5b9e7645065b4b3187114f07e3f402f | https://www.uniprot.org | None | 2024-03 | None | 2024-12-03 08:31:03.366072+00:00 | 1 |
25 | 01RW | bionty.Protein | mouse | uniprot | False | True | Uniprot | s3://bionty-assets/df_mouse__uniprot__2024-03_... | b1b6a196eb853088d36198d8e3749ec4 | https://www.uniprot.org | None | 2024-03 | None | 2024-12-03 08:31:03.366146+00:00 | 1 |
28 | 3kDh | bionty.CellMarker | human | cellmarker | False | True | CellMarker | s3://bionty-assets/human_cellmarker_2.0_CellMa... | d565d4a542a5c7e7a06255975358e4f4 | http://bio-bigdata.hrbmu.edu.cn/CellMarker | None | 2.0 | None | 2024-12-03 08:31:03.366218+00:00 | 1 |
29 | 7bV5 | bionty.CellMarker | mouse | cellmarker | False | True | CellMarker | s3://bionty-assets/mouse_cellmarker_2.0_CellMa... | 189586732c63be949e40dfa6a3636105 | http://bio-bigdata.hrbmu.edu.cn/CellMarker | None | 2.0 | None | 2024-12-03 08:31:03.366242+00:00 | 1 |
30 | 6LyR | bionty.CellLine | all | clo | False | True | Cell Line Ontology | https://data.bioontology.org/ontologies/CLO/su... | ea58a1010b7e745702a8397a526b3a33 | https://bioportal.bioontology.org/ontologies/CLO | None | 2022-03-21 | None | 2024-12-03 08:31:03.366267+00:00 | 1 |
32 | 1Lhf | bionty.CellType | all | cl | False | True | Cell Ontology | http://purl.obolibrary.org/obo/cl/releases/202... | 8a8638a9e79567935793e5007704c650 | https://obophenotype.github.io/cell-ontology | None | 2024-05-15 | None | 2024-12-03 08:31:03.366315+00:00 | 1 |
40 | MUtA | bionty.Tissue | all | uberon | False | True | Uberon multi-species anatomy ontology | http://purl.obolibrary.org/obo/uberon/releases... | http://obophenotype.github.io/uberon | None | 2024-08-07 | None | 2024-12-03 08:31:03.366536+00:00 | 1 | |
49 | 2L2r | bionty.Disease | all | mondo | False | True | Mondo Disease Ontology | http://purl.obolibrary.org/obo/mondo/releases/... | c47e8edb894c01f2511dfe0751fbc428 | https://mondo.monarchinitiative.org | None | 2024-06-04 | None | 2024-12-03 08:31:03.366757+00:00 | 1 |
57 | 4ksw | bionty.Disease | human | doid | False | True | Human Disease Ontology | http://purl.obolibrary.org/obo/doid/releases/2... | bbefd72247d638edfcd31ec699947407 | https://disease-ontology.org | None | 2024-05-29 | None | 2024-12-03 08:31:03.366951+00:00 | 1 |
65 | 2a1H | bionty.ExperimentalFactor | all | efo | False | True | The Experimental Factor Ontology | http://www.ebi.ac.uk/efo/releases/v3.70.0/efo.owl | https://bioportal.bioontology.org/ontologies/EFO | None | 3.70.0 | None | 2024-12-03 08:31:03.370072+00:00 | 1 | |
72 | 48fB | bionty.Phenotype | human | hp | False | True | Human Phenotype Ontology | https://github.com/obophenotype/human-phenotyp... | e0f2e534eb2ad44a4d45573ef27b508f | https://hpo.jax.org | None | 2024-04-26 | None | 2024-12-03 08:31:03.370261+00:00 | 1 |
77 | 4t7Q | bionty.Phenotype | mammalian | mp | False | True | Mammalian Phenotype Ontology | https://github.com/mgijax/mammalian-phenotype-... | 795d8378fe48ec13b41d01a86dd1c86c | https://github.com/mgijax/mammalian-phenotype-... | None | 2024-06-18 | None | 2024-12-03 08:31:03.370386+00:00 | 1 |
80 | sqPX | bionty.Phenotype | zebrafish | zp | False | True | Zebrafish Phenotype Ontology | https://github.com/obophenotype/zebrafish-phen... | 2231ebaa95becf8ff34a33c95a8d4350 | https://github.com/obophenotype/zebrafish-phen... | None | 2024-04-18 | None | 2024-12-03 08:31:03.370461+00:00 | 1 |
84 | 6S4q | bionty.Phenotype | all | pato | False | True | Phenotype And Trait Ontology | http://purl.obolibrary.org/obo/pato/releases/2... | 6b1eaacd3d453b34375ce2e31c16328a | https://github.com/pato-ontology/pato | None | 2024-03-28 | None | 2024-12-03 08:31:03.370580+00:00 | 1 |
86 | 7Ent | bionty.Pathway | all | go | False | True | Gene Ontology | https://data.bioontology.org/ontologies/GO/sub... | 7fa7ade5e3e26eab3959a7e4bc89ad4f | http://geneontology.org | None | 2024-06-17 | None | 2024-12-03 08:31:03.370630+00:00 | 1 |
91 | 3rm9 | BFXPipeline | all | lamin | False | True | Bioinformatics Pipeline | s3://bionty-assets/df_all__lamin__1.0.0__BFXpi... | https://lamin.ai | None | 1.0.0 | None | 2024-12-03 08:31:03.370752+00:00 | 1 | |
92 | ugaI | Drug | all | dron | False | True | Drug Ontology | https://data.bioontology.org/ontologies/DRON/s... | https://bioportal.bioontology.org/ontologies/DRON | None | 2024-08-05 | None | 2024-12-03 08:31:03.370776+00:00 | 1 | |
96 | 1GbF | bionty.DevelopmentalStage | human | hsapdv | False | True | Human Developmental Stages | https://github.com/obophenotype/developmental-... | https://github.com/obophenotype/developmental-... | None | 2024-05-28 | None | 2024-12-03 08:31:03.370871+00:00 | 1 | |
98 | 10va | bionty.DevelopmentalStage | mouse | mmusdv | False | True | Mouse Developmental Stages | https://github.com/obophenotype/developmental-... | https://github.com/obophenotype/developmental-... | None | 2024-05-28 | None | 2024-12-03 08:31:03.370921+00:00 | 1 | |
100 | MJRq | bionty.Ethnicity | human | hancestro | False | True | Human Ancestry Ontology | https://github.com/EBISPOT/hancestro/raw/3.0/h... | 76dd9efda9c2abd4bc32fc57c0b755dd | https://github.com/EBISPOT/hancestro | None | 3.0 | None | 2024-12-03 08:31:03.370970+00:00 | 1 |
101 | 5JnV | BioSample | all | ncbi | False | True | NCBI BioSample attributes | s3://bionty-assets/df_all__ncbi__2023-09__BioS... | 918db9bd1734b97c596c67d9654a4126 | https://www.ncbi.nlm.nih.gov/biosample/docs/at... | None | 2023-09 | None | 2024-12-03 08:31:03.370995+00:00 | 1 |