Organism¶
lamindb provides access to the following public Organism ontologies through bionty:
Here we show how to access and search Organism ontologies to standardize new data.
import bionty as bt
import pandas as pd
PublicOntology objects¶
Let us create a public ontology accessor with .public
method, which chooses a default public ontology source from Source
.
It’s a PublicOntology object, which you can think about as a public registry:
organisms = bt.Organism.public(organism="vertebrates")
organisms
→ connected lamindb: testuser1/test-public-ontologies
PublicOntology
Entity: Organism
Organism: vertebrates
Source: ensembl, release-112
#terms: 324
As for registries, you can export the ontology as a DataFrame
:
df = organisms.df()
df.head()
scientific_name | division | ontology_id | assembly | assembly_accession | genebuild | variation | microarray | pan_compara | peptide_compara | genome_alignments | other_alignments | core_db | species_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
name | ||||||||||||||
spiny chromis | acanthochromis_polyacanthus | EnsemblVertebrates | NCBITaxon:80966 | ASM210954v1 | GCA_002109545.1 | 2018-05-Ensembl/2020-03 | N | N | N | Y | Y | Y | acanthochromis_polyacanthus_core_112_1 | 1 |
eurasian sparrowhawk | accipiter_nisus | EnsemblVertebrates | NCBITaxon:211598 | Accipiter_nisus_ver1.0 | GCA_004320145.1 | 2019-07-Ensembl/2019-09 | N | N | N | N | N | Y | accipiter_nisus_core_112_1 | 1 |
giant panda | ailuropoda_melanoleuca | EnsemblVertebrates | NCBITaxon:9646 | ASM200744v2 | GCA_002007445.2 | 2020-05-Ensembl/2020-06 | N | N | N | Y | Y | Y | ailuropoda_melanoleuca_core_112_2 | 1 |
yellow-billed parrot | amazona_collaria | EnsemblVertebrates | NCBITaxon:241587 | ASM394721v1 | GCA_003947215.1 | 2019-07-Ensembl/2019-09 | N | N | N | N | N | Y | amazona_collaria_core_112_1 | 1 |
midas cichlid | amphilophus_citrinellus | EnsemblVertebrates | NCBITaxon:61819 | Midas_v5 | GCA_000751415.1 | 2018-05-Ensembl/2018-07 | N | N | N | Y | Y | Y | amphilophus_citrinellus_core_112_5 | 1 |
Unlike registries, you can also export it as a Pronto object via public.ontology
.
Look up terms¶
As for registries, terms can be looked up with auto-complete:
lookup = organisms.lookup()
The .
accessor provides normalized terms (lower case, only contains alphanumeric characters and underscores):
lookup.giant_panda
Organism(name='giant panda', scientific_name='ailuropoda_melanoleuca', division='EnsemblVertebrates', ontology_id='NCBITaxon:9646', assembly='ASM200744v2', assembly_accession='GCA_002007445.2', genebuild='2020-05-Ensembl/2020-06', variation='N', microarray='N', pan_compara='N', peptide_compara='Y', genome_alignments='Y', other_alignments='Y', core_db='ailuropoda_melanoleuca_core_112_2', species_id=1)
To look up the exact original strings, convert the lookup object to dict and use the []
accessor:
lookup_dict = lookup.dict()
lookup_dict["giant panda"]
Organism(name='giant panda', scientific_name='ailuropoda_melanoleuca', division='EnsemblVertebrates', ontology_id='NCBITaxon:9646', assembly='ASM200744v2', assembly_accession='GCA_002007445.2', genebuild='2020-05-Ensembl/2020-06', variation='N', microarray='N', pan_compara='N', peptide_compara='Y', genome_alignments='Y', other_alignments='Y', core_db='ailuropoda_melanoleuca_core_112_2', species_id=1)
By default, the name
field is used to generate lookup keys. You can specify another field to look up:
lookup = organisms.lookup(organisms.scientific_name)
lookup.ailuropoda_melanoleuca
Organism(name='giant panda', scientific_name='ailuropoda_melanoleuca', division='EnsemblVertebrates', ontology_id='NCBITaxon:9646', assembly='ASM200744v2', assembly_accession='GCA_002007445.2', genebuild='2020-05-Ensembl/2020-06', variation='N', microarray='N', pan_compara='N', peptide_compara='Y', genome_alignments='Y', other_alignments='Y', core_db='ailuropoda_melanoleuca_core_112_2', species_id=1)
Search terms¶
Search behaves in the same way as it does for registries:
organisms.search("rabbit").head(3)
name | scientific_name | division | assembly | assembly_accession | genebuild | variation | microarray | pan_compara | peptide_compara | genome_alignments | other_alignments | core_db | species_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ontology_id | ||||||||||||||
NCBITaxon:9986 | rabbit | oryctolagus_cuniculus | EnsemblVertebrates | OryCun2.0 | GCA_000003625.1 | 2009-11-Ensembl/2019-05 | N | Y | N | Y | Y | Y | oryctolagus_cuniculus_core_112_2 | 1 |
By default, search also covers synonyms and all other fileds containing strings:
organisms.search("sapiens").head(3)
name | scientific_name | division | assembly | assembly_accession | genebuild | variation | microarray | pan_compara | peptide_compara | genome_alignments | other_alignments | core_db | species_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ontology_id | ||||||||||||||
NCBITaxon:9606 | human | homo_sapiens | EnsemblVertebrates | GRCh38.p14 | GCA_000001405.29 | 2014-01-Ensembl/2023-12 | Y | Y | Y | Y | Y | Y | homo_sapiens_core_112_38 | 1 |
Search specific field (by default, search is done on all fields containing strings):
organisms.search(
"oryctolagus_cuniculus",
field=organisms.scientific_name,
).head()
name | scientific_name | division | assembly | assembly_accession | genebuild | variation | microarray | pan_compara | peptide_compara | genome_alignments | other_alignments | core_db | species_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ontology_id | ||||||||||||||
NCBITaxon:9986 | rabbit | oryctolagus_cuniculus | EnsemblVertebrates | OryCun2.0 | GCA_000003625.1 | 2009-11-Ensembl/2019-05 | N | Y | N | Y | Y | Y | oryctolagus_cuniculus_core_112_2 | 1 |
Standardize Organism identifiers¶
Let us generate a DataFrame
that stores a number of Organism identifiers, some of which corrupted:
df_orig = pd.DataFrame(
index=[
"spiny chromis",
"silver-eye",
"platyfish",
"california sea lion",
"This organism does not exist",
]
)
df_orig
spiny chromis |
---|
silver-eye |
platyfish |
california sea lion |
This organism does not exist |
We can check whether any of our values are validated against the ontology reference:
validated = organisms.validate(df_orig.index, organisms.name)
df_orig.index[~validated]
! 1 unique term (20.00%) is not validated: 'This organism does not exist'
Index(['This organism does not exist'], dtype='object')
Ontology source versions¶
For any given entity, we can choose from a number of versions:
bt.Source.filter(entity="bionty.Organism").df()
Show code cell output
uid | entity | organism | name | in_db | currently_used | description | url | md5 | source_website | dataframe_artifact_id | version | run_id | created_at | created_by_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
id | |||||||||||||||
1 | 33TU | bionty.Organism | vertebrates | ensembl | False | True | Ensembl | https://ftp.ensembl.org/pub/release-112/specie... | 0ec37e77f4bc2d0b0b47c6c62b9f122d | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365482+00:00 | 1 |
2 | 1SRH | bionty.Organism | vertebrates | ensembl | False | False | Ensembl | https://ftp.ensembl.org/pub/release-111/specie... | 2846df83899eaa61f8043db4c036e883 | https://www.ensembl.org | None | release-111 | None | 2024-12-03 08:31:03.365556+00:00 | 1 |
3 | 6I0P | bionty.Organism | vertebrates | ensembl | False | False | Ensembl | https://ftp.ensembl.org/pub/release-110/specie... | f3faf95648d3a2b50fd3625456739706 | https://www.ensembl.org | None | release-110 | None | 2024-12-03 08:31:03.365588+00:00 | 1 |
4 | 2m0D | bionty.Organism | vertebrates | ensembl | False | False | Ensembl | https://ftp.ensembl.org/pub/release-109/specie... | 7595bb989f5fec07eaca5e2138f67bd4 | https://www.ensembl.org | None | release-109 | None | 2024-12-03 08:31:03.365618+00:00 | 1 |
5 | 7MMd | bionty.Organism | vertebrates | ensembl | False | False | Ensembl | https://ftp.ensembl.org/pub/release-108/specie... | d97c1ee302e4072f5f5c7850eff0b642 | https://www.ensembl.org | None | release-108 | None | 2024-12-03 08:31:03.365646+00:00 | 1 |
6 | 6bbV | bionty.Organism | bacteria | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/bacte... | ee28510ed5586ea7ab4495717c96efc8 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365673+00:00 | 1 |
7 | 6s9n | bionty.Organism | fungi | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/fungi/releas... | dbcde58f4396ab8b2480f7fe9f83df8a | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365700+00:00 | 1 |
8 | 2PmT | bionty.Organism | metazoa | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/metazoa/rele... | 424636a574fec078a61cbdddb05f9132 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365726+00:00 | 1 |
9 | 7GPH | bionty.Organism | plants | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/plant... | eadaa1f3e527e4c3940c90c7fa5c8bf4 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365751+00:00 | 1 |
10 | 4tsk | bionty.Organism | all | ncbitaxon | False | True | NCBItaxon Ontology | s3://bionty-assets/df_all__ncbitaxon__2023-06-... | 00d97ba65627f1cd65636d2df22ea76c | https://github.com/obophenotype/ncbitaxon | None | 2023-06-20 | None | 2024-12-03 08:31:03.365776+00:00 | 1 |
# only lists the sources that are currently used
bt.Source.filter(entity="bionty.Organism", currently_used=True).df()
uid | entity | organism | name | in_db | currently_used | description | url | md5 | source_website | dataframe_artifact_id | version | run_id | created_at | created_by_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
id | |||||||||||||||
1 | 33TU | bionty.Organism | vertebrates | ensembl | False | True | Ensembl | https://ftp.ensembl.org/pub/release-112/specie... | 0ec37e77f4bc2d0b0b47c6c62b9f122d | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365482+00:00 | 1 |
6 | 6bbV | bionty.Organism | bacteria | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/bacte... | ee28510ed5586ea7ab4495717c96efc8 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365673+00:00 | 1 |
7 | 6s9n | bionty.Organism | fungi | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/fungi/releas... | dbcde58f4396ab8b2480f7fe9f83df8a | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365700+00:00 | 1 |
8 | 2PmT | bionty.Organism | metazoa | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/metazoa/rele... | 424636a574fec078a61cbdddb05f9132 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365726+00:00 | 1 |
9 | 7GPH | bionty.Organism | plants | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/plant... | eadaa1f3e527e4c3940c90c7fa5c8bf4 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365751+00:00 | 1 |
10 | 4tsk | bionty.Organism | all | ncbitaxon | False | True | NCBItaxon Ontology | s3://bionty-assets/df_all__ncbitaxon__2023-06-... | 00d97ba65627f1cd65636d2df22ea76c | https://github.com/obophenotype/ncbitaxon | None | 2023-06-20 | None | 2024-12-03 08:31:03.365776+00:00 | 1 |
When instantiating a Bionty object, we can choose a source or version:
source = bt.Source.filter(
name="ensembl", version="release-110", organism="vertebrates"
).one()
organisms= bt.Organism.public(source=source)
organisms
PublicOntology
Entity: Organism
Organism: vertebrates
Source: ensembl, release-110
#terms: 317
The currently used ontologies can be displayed using:
bt.Source.filter(currently_used=True).df()
Show code cell output
uid | entity | organism | name | in_db | currently_used | description | url | md5 | source_website | dataframe_artifact_id | version | run_id | created_at | created_by_id | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
id | |||||||||||||||
1 | 33TU | bionty.Organism | vertebrates | ensembl | False | True | Ensembl | https://ftp.ensembl.org/pub/release-112/specie... | 0ec37e77f4bc2d0b0b47c6c62b9f122d | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365482+00:00 | 1 |
6 | 6bbV | bionty.Organism | bacteria | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/bacte... | ee28510ed5586ea7ab4495717c96efc8 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365673+00:00 | 1 |
7 | 6s9n | bionty.Organism | fungi | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/fungi/releas... | dbcde58f4396ab8b2480f7fe9f83df8a | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365700+00:00 | 1 |
8 | 2PmT | bionty.Organism | metazoa | ensembl | False | True | Ensembl | http://ftp.ensemblgenomes.org/pub/metazoa/rele... | 424636a574fec078a61cbdddb05f9132 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365726+00:00 | 1 |
9 | 7GPH | bionty.Organism | plants | ensembl | False | True | Ensembl | https://ftp.ensemblgenomes.ebi.ac.uk/pub/plant... | eadaa1f3e527e4c3940c90c7fa5c8bf4 | https://www.ensembl.org | None | release-57 | None | 2024-12-03 08:31:03.365751+00:00 | 1 |
10 | 4tsk | bionty.Organism | all | ncbitaxon | False | True | NCBItaxon Ontology | s3://bionty-assets/df_all__ncbitaxon__2023-06-... | 00d97ba65627f1cd65636d2df22ea76c | https://github.com/obophenotype/ncbitaxon | None | 2023-06-20 | None | 2024-12-03 08:31:03.365776+00:00 | 1 |
11 | 4UGN | bionty.Gene | human | ensembl | False | True | Ensembl | s3://bionty-assets/df_human__ensembl__release-... | 4ccda4d88720a326737376c534e8446b | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365801+00:00 | 1 |
15 | 4r4f | bionty.Gene | mouse | ensembl | False | True | Ensembl | s3://bionty-assets/df_mouse__ensembl__release-... | 519cf7b8acc3c948274f66f3155a3210 | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.365901+00:00 | 1 |
19 | 4RPA | bionty.Gene | saccharomyces cerevisiae | ensembl | False | True | Ensembl | s3://bionty-assets/df_saccharomyces cerevisiae... | 11775126b101233525a0a9e2dd64edae | https://www.ensembl.org | None | release-112 | None | 2024-12-03 08:31:03.366000+00:00 | 1 |
22 | 3EYy | bionty.Protein | human | uniprot | False | True | Uniprot | s3://bionty-assets/df_human__uniprot__2024-03_... | b5b9e7645065b4b3187114f07e3f402f | https://www.uniprot.org | None | 2024-03 | None | 2024-12-03 08:31:03.366072+00:00 | 1 |
25 | 01RW | bionty.Protein | mouse | uniprot | False | True | Uniprot | s3://bionty-assets/df_mouse__uniprot__2024-03_... | b1b6a196eb853088d36198d8e3749ec4 | https://www.uniprot.org | None | 2024-03 | None | 2024-12-03 08:31:03.366146+00:00 | 1 |
28 | 3kDh | bionty.CellMarker | human | cellmarker | False | True | CellMarker | s3://bionty-assets/human_cellmarker_2.0_CellMa... | d565d4a542a5c7e7a06255975358e4f4 | http://bio-bigdata.hrbmu.edu.cn/CellMarker | None | 2.0 | None | 2024-12-03 08:31:03.366218+00:00 | 1 |
29 | 7bV5 | bionty.CellMarker | mouse | cellmarker | False | True | CellMarker | s3://bionty-assets/mouse_cellmarker_2.0_CellMa... | 189586732c63be949e40dfa6a3636105 | http://bio-bigdata.hrbmu.edu.cn/CellMarker | None | 2.0 | None | 2024-12-03 08:31:03.366242+00:00 | 1 |
30 | 6LyR | bionty.CellLine | all | clo | False | True | Cell Line Ontology | https://data.bioontology.org/ontologies/CLO/su... | ea58a1010b7e745702a8397a526b3a33 | https://bioportal.bioontology.org/ontologies/CLO | None | 2022-03-21 | None | 2024-12-03 08:31:03.366267+00:00 | 1 |
32 | 1Lhf | bionty.CellType | all | cl | False | True | Cell Ontology | http://purl.obolibrary.org/obo/cl/releases/202... | 8a8638a9e79567935793e5007704c650 | https://obophenotype.github.io/cell-ontology | None | 2024-05-15 | None | 2024-12-03 08:31:03.366315+00:00 | 1 |
40 | MUtA | bionty.Tissue | all | uberon | False | True | Uberon multi-species anatomy ontology | http://purl.obolibrary.org/obo/uberon/releases... | http://obophenotype.github.io/uberon | None | 2024-08-07 | None | 2024-12-03 08:31:03.366536+00:00 | 1 | |
49 | 2L2r | bionty.Disease | all | mondo | False | True | Mondo Disease Ontology | http://purl.obolibrary.org/obo/mondo/releases/... | c47e8edb894c01f2511dfe0751fbc428 | https://mondo.monarchinitiative.org | None | 2024-06-04 | None | 2024-12-03 08:31:03.366757+00:00 | 1 |
57 | 4ksw | bionty.Disease | human | doid | False | True | Human Disease Ontology | http://purl.obolibrary.org/obo/doid/releases/2... | bbefd72247d638edfcd31ec699947407 | https://disease-ontology.org | None | 2024-05-29 | None | 2024-12-03 08:31:03.366951+00:00 | 1 |
65 | 2a1H | bionty.ExperimentalFactor | all | efo | False | True | The Experimental Factor Ontology | http://www.ebi.ac.uk/efo/releases/v3.70.0/efo.owl | https://bioportal.bioontology.org/ontologies/EFO | None | 3.70.0 | None | 2024-12-03 08:31:03.370072+00:00 | 1 | |
72 | 48fB | bionty.Phenotype | human | hp | False | True | Human Phenotype Ontology | https://github.com/obophenotype/human-phenotyp... | e0f2e534eb2ad44a4d45573ef27b508f | https://hpo.jax.org | None | 2024-04-26 | None | 2024-12-03 08:31:03.370261+00:00 | 1 |
77 | 4t7Q | bionty.Phenotype | mammalian | mp | False | True | Mammalian Phenotype Ontology | https://github.com/mgijax/mammalian-phenotype-... | 795d8378fe48ec13b41d01a86dd1c86c | https://github.com/mgijax/mammalian-phenotype-... | None | 2024-06-18 | None | 2024-12-03 08:31:03.370386+00:00 | 1 |
80 | sqPX | bionty.Phenotype | zebrafish | zp | False | True | Zebrafish Phenotype Ontology | https://github.com/obophenotype/zebrafish-phen... | 2231ebaa95becf8ff34a33c95a8d4350 | https://github.com/obophenotype/zebrafish-phen... | None | 2024-04-18 | None | 2024-12-03 08:31:03.370461+00:00 | 1 |
84 | 6S4q | bionty.Phenotype | all | pato | False | True | Phenotype And Trait Ontology | http://purl.obolibrary.org/obo/pato/releases/2... | 6b1eaacd3d453b34375ce2e31c16328a | https://github.com/pato-ontology/pato | None | 2024-03-28 | None | 2024-12-03 08:31:03.370580+00:00 | 1 |
86 | 7Ent | bionty.Pathway | all | go | False | True | Gene Ontology | https://data.bioontology.org/ontologies/GO/sub... | 7fa7ade5e3e26eab3959a7e4bc89ad4f | http://geneontology.org | None | 2024-06-17 | None | 2024-12-03 08:31:03.370630+00:00 | 1 |
91 | 3rm9 | BFXPipeline | all | lamin | False | True | Bioinformatics Pipeline | s3://bionty-assets/df_all__lamin__1.0.0__BFXpi... | https://lamin.ai | None | 1.0.0 | None | 2024-12-03 08:31:03.370752+00:00 | 1 | |
92 | ugaI | Drug | all | dron | False | True | Drug Ontology | https://data.bioontology.org/ontologies/DRON/s... | https://bioportal.bioontology.org/ontologies/DRON | None | 2024-08-05 | None | 2024-12-03 08:31:03.370776+00:00 | 1 | |
96 | 1GbF | bionty.DevelopmentalStage | human | hsapdv | False | True | Human Developmental Stages | https://github.com/obophenotype/developmental-... | https://github.com/obophenotype/developmental-... | None | 2024-05-28 | None | 2024-12-03 08:31:03.370871+00:00 | 1 | |
98 | 10va | bionty.DevelopmentalStage | mouse | mmusdv | False | True | Mouse Developmental Stages | https://github.com/obophenotype/developmental-... | https://github.com/obophenotype/developmental-... | None | 2024-05-28 | None | 2024-12-03 08:31:03.370921+00:00 | 1 | |
100 | MJRq | bionty.Ethnicity | human | hancestro | False | True | Human Ancestry Ontology | https://github.com/EBISPOT/hancestro/raw/3.0/h... | 76dd9efda9c2abd4bc32fc57c0b755dd | https://github.com/EBISPOT/hancestro | None | 3.0 | None | 2024-12-03 08:31:03.370970+00:00 | 1 |
101 | 5JnV | BioSample | all | ncbi | False | True | NCBI BioSample attributes | s3://bionty-assets/df_all__ncbi__2023-09__BioS... | 918db9bd1734b97c596c67d9654a4126 | https://www.ncbi.nlm.nih.gov/biosample/docs/at... | None | 2023-09 | None | 2024-12-03 08:31:03.370995+00:00 | 1 |