##### Methylation

DNA methylation patterns vary with age, disease, and tissue type,
which makes them useful for both diagnostics and biological age
prediction.

#### A database for methylation profiles

Ying *et al.* (2024) collected 220k human DNA methylation profiles
from 5k datasets through the EWAS Data Hub and the Clockbase agent and
converted the raw files to parquet files. The datasets are available
from GitHub in the MethylGPT repo. For reference, the EWAS Data Hub
lists 180k samples in April 2026:

Ying *et al.*'s datasets are available at
lamin.ai/laminlabs/methyldata with additional annotations. You can,
e.g., filter by disease status, demographics, or tissue on the UI or
with "lamindb".

#### An example use case: age prediction

Here is a tutorial where we walk through how to train a ML model to
estimate age.